Articles, Studies and Applications


This page contains links to articles exploring the use of the TCL Analyzer. Please select the article you want to download and choose the desired file by clicking on the appropriate icon (DOC, ZIP or PDF File).







Validation studies and general articles





Acute Decompensated Heart Failure is Associated with Increased Serum Level of Oxidative Stress
Offer Amir, Sergei Shnizer, Abraham Z. Reznick, Ruthie E. Amir., Rafael Wolff, Ori Rogowski, HagarPaz, Basil S. Lewis
Dept. of Cardiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Heart Failure Clinic, Lin Medical Center, Haifa, Israel.
Lumitest Ltd, Haifa, Israel.


European Heart Failure Society Annual Meeting, Milan, 2008, Abstracts p. 145.


Serum Oxidative Stress Level Correlates with Clinical Parameters in Chronic Systolic Heart Failure Patients
Offer Amir, Hagar Paz, Ori Rogowski, Marina Barshai, Moran Sagiv, Sergei Shnizer, Abraham Z. Reznick, Ruthie E. Amir.
Dept. of Cardiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Heart Failure Clinic, Lin Medical Center, Haifa, Israel.
Dept. of Anatomy and Cell Biology, The Rappaport Faculity of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Dept.of Genetics a. Mol.Biology, Wingate Institute, Netanya, Israel.
Lumitest Ltd, Haifa, Israel.


Clinical Cardiology 2008 (In Press)



The Effect of 100% Oxygen on Intestinal Preservation and Recovery Following Ischemia-Reperfusion Injury in Rats
Igor Sukhotnik, Vera Brod, Michael Lurie, Michael A. Rahat, Sergei Shnizer, Nitza Lahat, Jorge G. Mogilner, and Haim Bitterman.
Dept. of Pediatric Surgery and Pathalogy, Bnai Zion Medical Center, Haifa, Israel.
Ischemia-shock and Immunology research laboratories, Lady Davis Carmel Medical Center, Haifa, Israel.
The Rappaport Faculity of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Lumitest Ltd, Haifa, Israel.


Critical Care 2008 (In Press)



The Early Anti-Oxidant Effect of Carvedilol Predicts The Clinical Course in Congestive Heart Failure Patients.
Goldhammer E, Maor I, Shnizer S, Lanir A, Abinader EG
Departament of Cardiology, Bnai-Zion Medical Center and School of Medicine, Technion, Haifa, Israel
Lumitest Ltd, Haifa, Israel.

J Cardiovasc Med ( Hagerstown ). 2007 Jun; 8(6), p. 453-456
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Enhanced Oxidative Stress and Leucocyte Activation in Neoplastic Tissues of the Colon
Tova Rainis, Irit Maor, Amos Lanir, Sergey Shnizer and Alexandra Lavy
Bnai-Zion Medical Center, Gastroenterology Unit, Haifa, Israel
Bnai-Zion Medical Center, Departament of Biochemistry, Haifa, Israel
Lumitest Ltd, Haifa, Israel.

Dig Dis Sci. 2007 Feb; 52(2), p. 526-530
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Thermochemiluminescence (TCL) oxidizability assay - clinical and laboratory studies.
A.Z. Reznick, G. Brook, A. Hochman, T. Mamou, G. Zozulya, Y.Wollman, A. Iaina, R.M. Nagler, O. Hershkovich, S.V. Shnizer.

NATO Science series - Frontiers in neurodegenerative diseases and aging: Fundemental aspects, Clinical Perspectives and New Insights.
Edited by T.Osben and M.Chevion.
2004, Series I: Life and Behavioural Sciences - vol. 358, IOS Press. p. 40-55.
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Oxidative stress indices in follicular fluid as measured by thermochemiluminescence assay correlate with outcome parameters in vitro fertilization.
Zofnat Weiner-Megnazi, M.D., Liad Vardi, M.D., Arie Lissak, M.D., Sergei Shnizer, M.D., Ph.D., Abraham Zeev Reznick, Ph.D., David Ishai, M.D., Shirly Lahav-Baratz, Ph.D., Hanna Shiloh, M.Sc., Mara Koifman, M.Sc., and Martha Dimfeld, M.D.
IVF Unit, Departament of obstetics and gynecology, Carmiel Medical Center, Haifa, Israel
Lumitest Ltd., Haifa, Israel
The Bruce Rappaport Faculty of Medicine, Technion, Israel Instittute of Technology, Haifa, Israel

Fertility and Sterility. vol. 82, Suppl 3:1171-6, 2004.
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Oxidative stress indices in seminal plasma, as measured by the thermochemiluminescence assay, correlate with sperm parameters
Arie Lissak, M.D., Zofnat Weiner-Megnazi, M.D., Abraham Zeev Reznick, Ph.D., Sergei Shnizer, M.D., Ph.D., David Ishai, M.D., Bronislava Grach, M.Sc., Shirly Lahav-Baratz, Ph.D., Hanna Shiloh, M.Sc., Mara Koifman, M.Sc., and Martha Dimfeld, M.D.
IVF Unit, Departament of obstetics and gynecology, Carmiel Medical Center, Haifa, Israel
The Bruce Rappaport Faculty of Medicine, Technion, Israel Instittute of Technology, Haifa, Israel
Lumitest Ltd., Haifa, Israel

Fertility and Sterility, vol. 81, Suppl. 1:792-7, 2004.
See the abstract on PubMed
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Oxidative Stress in Hypertensive, Diabetic and Diabetic Hypertensive Rats
Joseph Friedman, Edna Peleg, Tamara Kagan, Sergei Shnizer and Talma Rosenthal
A J Chorley Institute of Hypertension, Chaim Sheba Medical Center, Tel-Hashomer, Israel.


American Journal of Hypertension, vol. 16, Issue 12 (December 2003), p. 1049-1052.
See the abstract on PubMed


Oxidative Stress in Hypertensive, Diabetic, and Diabetic Hypertensive Rats
Joseph Friedman, Edna Peleg, Tamara Kagan, Sergei Shnizer, and Talma Rosenthal
A.J. Chorley Institute for Hypertension (JF, EP, TR), Chaim Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel.
University of Tel Aviv, Sackler School of Medicine, Tel Aviv, Israel.
Lumitest Ltd. (TK, SS), Nesher, Israel.


American Journal of Hypertension 2003; vol. 16, p. 1049-1052.
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Modifications and oxidation of lipids and proteins in human serum detected by thermochemiluminescence.
Shnizer S, Kagan T, Lanir A, Maor I, Reznick AZ.
Lumitest Ltd, Nesher, Israel.
Department of Biochemistry, Bnai Zion Medical Center, Haifa, Israel.
The Bruce Rappoport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.


Luminescence 2003; vol. 18, p. 90-96.
Read abstract of this article at InterScience site.
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Contribution of protein components (protein carbonyls) to photon emission generated by Thermochemiluminescence
Dr. Abraham Z. Reznick
Department of Anatomy and cell Biology, Bruce Rappoport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.


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The use of TCL (Thermochemiluminescence) assay in detecting changes in intracellular Reactive Oxygen Species (ROS) in signal transduction experiments
Rony Seger and Joseph Friedman
Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.


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Thermochemiluminescence (TCL) as a method for assessing lipid peroxidation
Prof. Ayala Hochman, Dr. Tamara Kagan and Dr. Yehoshua Hochman
Dept. of Biochemistry, George S. Wise faculty of Life Sciences, Tel-Aviv University, Israel
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Examples of experimental & clinical work done using the Lumitest TCL Analyzer

(Full abstracts will follow soon)

A. Cardiovascular

A.1 The total oxidizability of sera from Chronic Heart Failure (CHF) patients correlates with its clinical state and BNP level
Offer Amir, Abraham Z. Reznick, Ruthie E. Amir, Rafael Wolf, Hagar Paz, Sigal Nisanov, Sergei Shnizer.
Dept. of Cardiology, Carmel Medical Center, Haifa, Israel.
Dept. of Anatomy and Cell Biology, The Rappaport Faculity of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Heart Failure Clinic, Lin Medical Center, Haifa, Israel.
Dept.of Genetics a. Mol.Biology, Wingate Institute, Netanya, Israel.
Lumitest Ltd, Haifa, Israel.
The Israel Society for Oxygen and Free Radical Research.
Faculty of Agricultural, Food and Enviromental Quality Sciebces, The Hebrew University of Jerusalem.
23rd Annual Meeting. December 9th 2007

A.2 Comparison of Plasma Oxidizability of STEMI (ST Elevation Myocardial Infarction) Patients Versus Non STEMI Patients Using a Real Time Thermochemiluminescence (TCL) Assay
Mich Kassirer, Ori Rogowski, Itzhak Shapira, Jack Serov, Pinhas Halpern, Yaffa Vered, Irena Azov, Sergei Shnizer, Abraham Z. Reznick, Shlomo Berliner
Dept. of Medicine, Tel-Aviv Sourasky Medical Center, affilated to Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Dept. of Emergency Medicine, affilated to Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Central Laboratory, Tel-Aviv Sourasky Medical Center, affilated to Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Lumitest Ltd, Haifa, Israel.
Dept. of Anatomy and Cell Biology, The Rappaport Faculity of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
The Israel Society for Oxygen and Free Radical Research, 22nd Annual Meeting, December 17th, 2006, p. 38.

A.3 Oxygen Derived Free Radicals Activity Following Thrombolysis with Streptokinase, t-PA and r-tPA Combined with Abciximab
E. Goldhammer, S. Shnizer*, N. Kleiman, I. Maor*, A. Lanir* and E.G. Abinader
Dept. of Cardiology, Bnei-Zion Medical Center & Faculty of Medicine. Technion. Haifa. Israel, * Dept. Of Biochemistry. Bnei-Zion Medical Center, Haifa, Israel

Coronary Artery Disease. Prevention to Intervention Proceedings of the 3rd International Congress on Coronary Artery Disease. Lyon (France), October 2-5, 2000

A.4 Serum Oxidative State Following Thrombolysis With Abciximab Combined Comparison To R-Pa Or With R-Pa in Streptokinase.
Maor I*, Goldhammer E **, Shnizer S *, Kagan T*. Abinader E.G**, Lanir A*
Departments of Biochemistry* and Cardiology **, Bnai Zion Medical Center, Faculty of Medicine**, Technion, Haifa, Israel
5th Czech National Congress of Clinical Biochemistry. May 26-31, 2001. Prague, Czech Republic

A.5 Increased Oxidative State In Amputated Subjects With Peripheral Vascular Disease: Studies In Patients With Atherosclerosis, Diabetes And Thromboangiitis Obliterans
Schor R*, Maor I*, Galin A**, Shnizer S*, Zer-Aviv F**, Bronfman M**. Lanir A*
Departments of Biochmistry * and Rehabilitation **, Bnai Zion Medical Center, Haifa, Israel
5th Czech National Congress of Clinical Biochemistry. May 26-31, 2001. Prague, Czech Republic

A.6 Oxidative Stress in SHR, the Cohen NIDDM Rat (CDR), and the Cohen Rosenthal Diabetic Hypertensive (CRDH) Rat
E. Peleg, J. Friedman*, S. Shnizer^, T. Rosenthal.
A J Chorley Institute for Hypertension, Chaim Sheba Medical Center, Tel Hashomer 52621 Israel, *Regional Laboratory, General Federation of Labor Health Fund, Petah Tikva. ^Lumitest Ltd., Nesher, Israel

10th International Symposium on SHR and Molecular Medicine. May 2-4, 2001. Berlin-Buch

B. Gynecology-Obstetrics-Fertility

B.1 Oxidative stress correlates with embryo quality in IVF.
Z. Weiner-Megnazi, L. Vardi, H. Shiloh, M. Koifman, S. Lahav-Baratz, S. Shnizer, M. Bar-Shai, A. Z. Reznick, D. Ishai, R. Auslander, and M. Dimfeld.
Annual Meeting of the European Society of Human Reproduction and Embryology
19-22 June, 2005, Copenhagen, Denmark, book of abstracts, p360.

B.2 Embryo guality in IVF correlates with oxidative stress indices in follicular fluid
Zofnat Weiner-Megnazi, Liad Vardi, Sergei Shnizer, Shirly Lahav-Baratz, Hanna Shiloh, Mara Koifman, Marina Bar-Shai, Abraham Zeev Reznick, David Ishai, Ron Auslander, and Martha Dimfeld.
IVF Unit, Departament of obstetics and gynecology, Carmiel Medical Center, Haifa, Lumitest Ltd., Haifa, The Bruce Rappaport Faculty of Medicine, Technion, Israel Instittute of Technology, Haifa, Israel

The 4th Congress of the Federation of the Israel Societies for Experemental Biology, February 7-10, 2005, Eilat, Israel.

B.3 Oxidative stress in embryo media correlate with fertilization and cleavage.
Z. Weiner-Megnazi, S. Shnizer, H. Shiloh, R. Auslander, D. Ishai, S. Lahav-Baratz, M. Koifman and M. Dirnfeld
IVF Unit, Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.

2th Annual meeting of the European Society of Human reproduction and Embryology (ESHRE), Berlin, Germany, June 27-30 2004

B.4 Electronically Excited Species (EES) In Follicular Fluid (FF) Indices Correlate With Women's Age And The Chances Of Conception In ART
Wiener - Megnazi Z., Ishai D., Shnizer S.*, Lahav - Baratz S., Shiloh H., Koifman M. Abramovici H., and Dirnfeld M.
IVF Unit,Department of OBGYN, Carmel Medical Center, 7 Michal St, Haifa, Israel *Lumitest Ltd.

Annual Meeting of the American Society for Reproductive Medicine, Seattle, Washington, October 12-17, 2002

B.5 Electronically Excited Species (EES) Indices In Seminal Plasma Correlates With Patients' Age And Sperm Motility Parameters In ART
Wiener - Megnazi Z., Grach B., Ishai D., Shnizer S., Lahav - Baratz S., Shiloh H, Koifman M., Calderon I. Dirnfeld M. and Abramovici H.
IVF unit, Department of OBGYN, Carmel Medical Center, Haifa, Israel.

Annual Meeting of the American Society for Reproductive Medicine, Seattle, Washington, October 12-17, 2002

B.6 A Novel Method In Vitro Fertilization Success By Analyzing Follicular Fluids By Thermochemiluminescence
Kees S(1,2), Friedman J.(3), Dor J.(1), Shnizer S.(4), and Amsterdam A.(2)
(1)IVF Unit, Sheba Medical Center. Tel-Hashomer, (2)Weizmann Institute of Science. Department of Cell Biology, (3)Regional laboratory Kupat Holim Klalit, Petah Tikva, (4)Lumitest. Ltd. Nesher

The Annual Meeting of the Israeli Society for Fertility Research. Tel-Aviv, May 30-31 2001

B.7 Thermochemiluminescence - A New Method For Assessing Fetal Lung Maturity.
S. Shnizer, R. Gonen, E. Taycher, A. Lanir, R.M. Lewinsky. Shinherg.
Departments of Biochemistry and Obstetrics & Gynecology, Bnai Zion Medical Center,

11th IFCC European Congress of Clinical Chemistry, Tampere, Finland. 28 June - 2 July 1995

B.8 Thermochemiluminescence Of Exogenous Surfactants (Curosurf, Survanta, Exosurf, Phosphatidylcholine), Natural Lung Surfactant And Its Use In Clinics And Research.
Z. Weintraub(1), S. Shnizer(2), A. Lanir(3), V. Gottfried(4) and D. Gershon(5).
1 Neonatal Department, Carmel Medical Center, Haifa, Israel. 2 Technion Enterpreneurial Park. Israel Institute of Technology, Haifa, Israel. 3 Department of Biochemistry, Bnei-Zion Medical Center, Haifa, Israel. 4Department of Chemistry, Technion-Israel Institute of Technology, Haifa, Israel. 5Department of Biology Technion-Israel Institute of Technology, Haifa, Israel.

9th International Workshop on Surfactant Replacement. Jerusalem, Israel, May 22-25 1994

C. ICU-Respiratory-Sepsis

C.1 Assessment Of Reactive Species (RS) In Bronchoalveolar Lavage Fluid In Acute Respiratory Distress Syndrome (ARDS) Patients By Thermochemiluminescence (TCL) Method
Krimerman Sh.(*), Shnizer S. (***), Dor I. (*). Kagan T. (*), Lanir A. (**)
(*) Department of ICU, Bnei -Zion Medical Center, Haifa, Israel (**) Department of Biochemistry, Faculty of Medicine, Technion, Haifa, Israel (***) Lumitest Ltd., Nesher, Israel

The Annual Meeting of the Israel Society for Oxygen and Free Radical Research. Haifa, Israel, December 5, 1999

C.2 Enhanced Oxidative Stress and Decreased Susceptibility to Oxidation of Serum Derived from Septic Patients
Maor I*, Dor Y**, Shnizer S***, Kagan T*, Lanir A*
Departments of Biochemistry* and Surgery**, Bnai Zion Medical Center, Haifa, Israel, ***Lumitest Ltd. Israel

The 36th Annual Meeting of the Israeli Society for Clinical Laboratory Sciences. Tel-Aviv, January 23-24, 2003

D. Nephrology

D.1 Thermochemiluminescence in Patients with Renal Failure
Keren D, Kagan T, Shnizer S, Lanir A
Department of Biochemistry, Bnai-Zion Medical Center, Haifa, Israel

The First Regional Meeting on Medical Sciences: The Roles of Free Radicals in Health and Disease. Jerusalem-Amman. March 22-27, 1998

D.2 Monitoring Oxidative Stress in Chronic Cardio-Renal Anemia (CRA) Syndrome Patients During Iron Infusion by Thermochemiluminescence
Yoram Wollman, Donald Sylverberg and Adrian Iaina.
Nephrology Department, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel

Nephrology Dialysis Transplantation, vol. 18 Supplement 4 (June 2003), p. 417

E. General Scientific Validation

E.1 Thermochemiluminescence as a Method for Determination of lipid Peroxidation
Sergei Shnizer, Tamara Kagan, Amos Lanir, Hanna Ben-Ari and Abraham Z. Reznick
Department of Morphological Sciences, Faculty of Medicine, Technion, Haifa, Israel

The First Regional Meeting on Medical Sciences: The Roles of Free Radicals in Health and Disease. Jerusalem-Amman. March 22-27, 1998

E.2 The Effect Of Vitamin C On Blood Serum Lipid Peroxidation Measured By Thermochemiluminescence
S. Shnizer, T. Kagan, A. Lanir, I. Maor
Dept of Biochemistry, Bnei Zion Medical Center; Haifa Israel; Lumitest Ltd., Nesher, Israel

The Annual Meeting of the Israel Society for Oxygen and Free Radical Research. Tel-Aviv, Israel. Dec. 24, 2000

E.3 Detection Of Chemical Modification And Oxidation In Body Fluids By Thermochemiluminescence (TCL) Method
Shnizer S. *, Kagan T.**, Reznick A.Z.***, Maor I.**, Lanir A.**.
*Lumitest Ltd ** Dept. of Biochemistry. Bnai Zion Medical Center, ***Faculty of Medicine, Technion, Haifa, Israel

IInd International Meeting on Oxidative Stress: Biochemistry and Pathophysiology. (Society for Free Radical Research - Europe). Valencia, Spain. Nov 30-Dec. 2, 2000

E.4 Thermochemiluminescence (TCL) Analyzer - A new Essay for Detection of Oxidized Lipids and Proteins
A.Z. Reznick(1) and S. Shnizer(2)
(1) Technion - Faculty of Medicine, Haifa, Israel and (2) Lumitest Ltd. Haifa, Israel

Frontiers in Neurodegenerative Disorders and Ageing: Fundamental Aspects, Clinical Perspectives and New Insights. Antalya, Turkey, May 26 - June 1, 2003

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